THCM stands for 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid and is an unstudied byproduct of THC that has received minimal consideration in scientific research. However, it exists and has been used as an indicator for marijuana use during gestation. Get the Best information about moon chocolate bar.
Explore indications, contraindications, off-label uses, and pharmacodynamics of THC synthetic analogs used for managing chemotherapy-induced nausea and vomiting and AIDS-related anorexia. This course is tailored to interprofessional teams.
What is THC-M?
THC-M, one of two widely recognized psychoactive compounds found in cannabis, is a monomethyl ether derivative known as THC, making up one-half of Delta-9 THC’s isomers and responsible for many psychoactive effects in cannabis plants.
THC, the primary cannabinoid found in cannabis, has long been linked with various health benefits. THC may help stimulate appetite, increase focus, alleviate pain, and promote sleep quality, in addition to relaxing body muscles and improving quality. Unfortunately, concern has been raised over potential adverse side effects caused by THC-M. To protect yourself against potential risks or benefits related to THC-M use before taking any cannabis-derived products.
THC-M shares similar chemical structures with Delta-9 THC and may possess comparable potencies and effects; however, as THC-M has yet to be isolated, it cannot be confirmed that this cannabinoid has intoxicating qualities.
THCM, or THC Metabolites (THCM), is an organic cannabinoid found naturally in marijuana plants and hemp plants, with unique chemical structures that allow it to bind more effectively with CB1 receptors in the brain than Delta-9 THC does – making THCM both potency-enhancing and long-acting; further research needs to be conducted before any conclusions can be drawn about any medical benefits it may hold.
Even though you can find THC-M products online, they rarely contain pure THC-M. Instead, these products have various cannabinoid byproducts and terpenes, which make it impossible to determine whether or not these will produce intoxicating effects.
As cannabis enthusiasts and cultivators search for every possible cannabinoid, it is essential to remember that further research must be completed before these compounds can be recommended or prescribed. Until this research and education have occurred, THC-approved indications should suffice until then. Keeping abreast of current research will assist clinicians (MDs, DOs, NPs, PAs, etc), specialists teams, or interprofessional teams to stay current regarding safe and effective THC formulation use.
How is THC-M made?
To produce THC-M, its precursor must first be converted to THCA through activating cannabinoid synthase enzyme THCAS employing specific phytochromes. Once made, this substance can be converted to THC by adding one more carbon atom and transforming it into the final form. This process is similar to how Delta-10, Delta-9, and Delta-8 THC are made; however, unlike them, THC-M is not considered an actual cannabinoid due to lacking double bonds at the C-1 position, so it is not subject to regulation similar to Delta-9 THC.
Natural forms of THCM can be found in cannabis as a byproduct of THC metabolism. Biotechnological methods also exist for its production; to this end, scientists have identified and cloned the gene needed to produce this cannabinoid (THCAS). They then utilized its cDNA sequence to create a fermentation-friendly expression system (Sirikantaramas et al., 1995).
Smoking THCM produces similar psychoactive effects as THC. This can include feelings of euphoria, relaxation, and sedation, as well as helping cancer patients reduce nausea and vomiting during chemotherapy. Furthermore, it has also been used as a marker to determine whether an unborn fetus was exposed to cannabis smoke during gestation (Sirikantaramas & Taura, 1999).
Though THC-M is naturally present, its safety cannot yet be established. Since THC-M is only found at low concentrations within cannabis plants, it is unlikely to pose more risk than any other compounds.
THC-M is now widely available in products like tinctures, edibles, and cartridges. While THC-M can provide users with a more intense high than traditional THC, it should still be consumed carefully due to its unknown risks and potentially unpredictable impact on users’ experiences. Also, many such products contain other cannabinoid byproducts and terpenes, making their exact effects challenging to ascertain.
Does THC-M get you high?
THC and THCM are two cannabinoids that interact with our endocannabinoid system to produce different effects in our bodies. THC is best known for its psychoactive effects; THCM may also provide some medical advantages. With longer chemical chains than THC, THCM has less ability to make us high, yet still affects brain CB1 receptors to stimulate appetite or relieve nausea in low doses; at higher concentrations, it may produce an intense cerebral buzz.
THCM can be found in cannabis plants and extracted to produce various products, including tinctures, edibles, and vape carts. Most often available as hemp-based products that do not exceed 0.3% delta-9 THC by dry weight concentration; as per Farm Bill regulations, any cannabinoid product produced or sold in the US must come from hemp sources to be legal; production and sale of THC-M in US markets without meeting these criteria is illegal.
The THC-M cannabinoid has not been widely researched, and its effects and safety remain unknown. However, based on its chemical makeup, THC-M may have properties similar to THC, with an intoxicating effect and three times more potency than Delta 9 THC.
When inhaled, THC-M is absorbed by the bloodstream and quickly travels to the brain, where it bonds to CB1 receptors, producing psychoactive effects including mood alteration and perceptual shifts, increased heart rate and blood pressure, and can trigger anxiety in some individuals.
THCM is not generally considered safe, as its high doses may produce psychoactive effects and side effects, including dizziness, tremors, nausea, and dry mouth. Furthermore, overdosing on this substance may lead to cannabis poisoning (although usually non-fatal); medical attention must be sought immediately should symptoms present themselves, as this requires immediate medical treatment.
What is the safety of THC-M?
THC-M is a naturally occurring cannabinoid that is not chemically synthesized; therefore, it does not present the same health risks as synthetic cannabinoids. Still, as with all cannabinoids, they should not be taken in high doses, particularly by individuals with preexisting medical conditions like heart disease or schizophrenia; similarly, it is advised to refrain from taking THC-M during pregnancy or breastfeeding as its consumption could pose risks.
THC-M is widely found in edible products such as gummies, chocolate bars, and candy. While its potency depends on how well a product was manufactured, InfiniteCAL has extensively validated edibles through internal sample recovery experiments and external blind proficiency tests to measure their potency levels accurately.
One of the primary goals of cannabis testing is ensuring products contain only safe levels of THC, so InfiniteCAL utilizes standard laboratory extraction and analysis methods proven effective at detecting this cannabinoid. We utilize HPLC systems, mass spectrometers, and detectors as instruments explicitly calibrated to test for THC-M and are maintained by trained technicians.
One way InfiniteCAL ensures its test results are accurate is by comparing them against those from other labs. We participate in blind proficiency tests regularly with different laboratories to compare our results against theirs and ensure we deliver high-quality testing services.
InfiniteCAL’s laboratory has been accredited by an independent third party to perform THC-M testing according to our internal quality standards, using proven methodologies and equipment, rigorous quality assurance/quality control measures, and providing continuous quality assurance services. Customers requesting certification can obtain it.
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